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Nano-assembly of amyloid β peptide: role of the hairpin fold. Altmetric calculates a score based on the online attention an article receives. Each coloured.
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DOI: ; Published online by Cambridge University Press: 25 May
Continue to access RSC content when you are not at your institution. Follow our step-by-step guide. Deoxyribonucleic acid DNA and ribonucleic acid RNA have remarkably similar chemical structures, but despite this, they play significantly different roles in modern biology. In this article, we explore the possible conformations of DNA and RNA hairpins to better understand the fundamental differences in structure formation and stability.
We use large parallel temperature replica exchange molecular dynamics ensembles to sample the full conformational landscape of these hairpin molecules so that we can identify the stable structures formed by the hairpin sequence. Our simulations show RNA adopts a narrower distribution of folded structures compared to DNA at room temperature, which forms both hairpins and many unfolded conformations.
RNA is capable of forming twice as many hydrogen bonds than DNA which results in a higher melting temperature.
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